Interferon-? Stimulates the Survival and Influences the Development of Bipotential Granulocyte-Macrophage Colony-Forming Cells
نویسندگان
چکیده
The effects of interferon-y (IFN-y) on a highly enriched population of granulocyte-macrophage colony-forming cells (GM-CFC) were assessed. When added with myeloid growth factors (interleukin-3 [IL-3], granulocyte-macrophage colonystimulating factor [GM-CSF], or macrophage-CSF [M-CSF]), IFN-y inhibited the formation of colonies in soft agar assays. Furthermore IFNy stimulated an increase in the number of macrophages present in colonies formed in the presence of IL-3.lFN-y also inhibited M-CSF-, GM-CSF-, or lL-3-stimulated [aH]-thymidine incorporation in highly enriched GM-CFC. However, when added in the absence of hematopoietic growth factors, IFN-y promoted the survival of GM-CFC and
منابع مشابه
Interferon-gamma stimulates the survival and influences the development of bipotential granulocyte-macrophage colony-forming cells.
The effects of interferon-gamma (IFN-gamma) on a highly enriched population of granulocyte-macrophage colony-forming cells (GM-CFC) were assessed. When added with myeloid growth factors (interleukin-3 [IL-3], granulocyte-macrophage colony-stimulating factor [GM-CSF], or macrophage-CSF [M-CSF]), IFN-gamma inhibited the formation of colonies in soft agar assays. Furthermore IFN-gamma stimulated a...
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